Genetic Test : Health & Medical

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Pharmacogenetics-Based Warfarin Dosing in Children

Pharmacogenetics-Based Warfarin Dosing in Children

This review describes the two main types of pharmacogenetic-based warfarin dose prediction models and their applicability to children. What are their respective advantages and limitations?......[Read More]
The Clinical Role of GWAS 10 Years On... and On

The Clinical Role of GWAS 10 Years On... and On

Mustering enthusiasm for genome-wide association studies right now might be difficult, but there are too many signs that we can't afford to quit now.......[Read More]
A Urinary Biomarker Associated With CYP2D6 Activity

A Urinary Biomarker Associated With CYP2D6 Activity

CYP2D6 is crucial for the metabolism of many drugs, but currently phenotyping requires administration of a probe drug. Could a urinary biomarker provide a noninvasive method of CYP2D6 phenotyping?......[Read More]
Genes and Beans

Genes and Beans

How can pharmacogenomics be applied to post-transplant immunosuppressive therapy? This review explores how genetic profiles may inform drug selection, improving efficacy and limiting toxicity.......[Read More]
Genetic Variant Predicts Risk for Radiation Pneumonitis in NSCLC

Genetic Variant Predicts Risk for Radiation Pneumonitis in NSCLC

Dr. Maurie Markman comments on a study published in the JCO describing the use of a TGF-beta1 gene variant to predict the risk for radiation pneumonitis in patients with NSCLC.......[Read More]
VEGF Pathway Polymorphisms as Prognostic Factors in Cancer

VEGF Pathway Polymorphisms as Prognostic Factors in Cancer

This review summarizes current research on antiangiogenic agents for cancer, as well as predictive and prognostic markers in the VEGF pathway. What challenges and pitfalls remain for future therapies?......[Read More]
Tacrolimus Concentrations in Kidney Transplant Recipients

Tacrolimus Concentrations in Kidney Transplant Recipients

This study examines the genetic factors which might contribute to the variability of tacrolimus pharmacokinetics in kidney transplant recipients.......[Read More]
Pediatric Perspective on Pharmacogenomics

Pediatric Perspective on Pharmacogenomics

Pharmacogenomics has the potential to impact treatment of many childhood diseases, from asthma and cancer to JRA and growth disorders. What's the status of pharmacogenomic research in pediatrics?......[Read More]
Quantifying and Qualifying Mutations: We're on Our Way

Quantifying and Qualifying Mutations: We're on Our Way

Dr. George Church considers how new ways to assess genetic mutations will affect our understanding of their clinical relevance.......[Read More]
Preventing Head and Neck Tumors the Genetic Way

Preventing Head and Neck Tumors the Genetic Way

Chemoprevention of head and neck cancers with retinoic acid showed mixed trial results. But as Dr. Maurie Markman explains, genetics might help in predicting responders.......[Read More]
Predicting Sensitivity to Gemcitabine and Cisplatin in NCSLC

Predicting Sensitivity to Gemcitabine and Cisplatin in NCSLC

Does the presence of polymorphisms in certain genes and alterations in their miRNA expression affect in vitro chemosensitivity to cisplatin and gemcitabine?......[Read More]
miRNAs in Breast Cancer: Ready for Real Time?

miRNAs in Breast Cancer: Ready for Real Time?

miRNAs are now recognized as critical regulators of gene expression. What role do they play in breast cancer pathogenesis, and can they serve as biomarkers and potential therapeutic targets?......[Read More]
A New Therapeutic Target for Hairy Cell Leukemia

A New Therapeutic Target for Hairy Cell Leukemia

Dr. Maurie Markman reviews a recent paper identifying a druggable BRAF mutation in patients with hairy cell leukemia.......[Read More]
Redefining Personalized Medicine in the Primary Care Setting

Redefining Personalized Medicine in the Primary Care Setting

What should a personalized medicine approach be in a primary care practice? Dr. Scott Joy considers both patient and provider perspectives and their impact on the practice of medicine moving forward.......[Read More]
Genomic Data Abound -- Are We Prepared to Use Them?

Genomic Data Abound -- Are We Prepared to Use Them?

Dr. Atul Butte considers the extraordinary strides made in amassing genomic data and the challenges ahead in knowing how to use them effectively.......[Read More]