Genetic Test : Health & Medical

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Pharmacogenetics of Statins: Achievements and Perspectives

Pharmacogenetics of Statins: Achievements and Perspectives

There is large variability in clinical response to statin therapy. This review examines genetic factors which may contribute to the lipid-lowering effectiveness of statins and their side effects.......[Read More]
A Urinary Biomarker Associated With CYP2D6 Activity

A Urinary Biomarker Associated With CYP2D6 Activity

CYP2D6 is crucial for the metabolism of many drugs, but currently phenotyping requires administration of a probe drug. Could a urinary biomarker provide a noninvasive method of CYP2D6 phenotyping?......[Read More]
Genes and Beans

Genes and Beans

How can pharmacogenomics be applied to post-transplant immunosuppressive therapy? This review explores how genetic profiles may inform drug selection, improving efficacy and limiting toxicity.......[Read More]
Genetic Variant Predicts Risk for Radiation Pneumonitis in NSCLC

Genetic Variant Predicts Risk for Radiation Pneumonitis in NSCLC

Dr. Maurie Markman comments on a study published in the JCO describing the use of a TGF-beta1 gene variant to predict the risk for radiation pneumonitis in patients with NSCLC.......[Read More]
VEGF Pathway Polymorphisms as Prognostic Factors in Cancer

VEGF Pathway Polymorphisms as Prognostic Factors in Cancer

This review summarizes current research on antiangiogenic agents for cancer, as well as predictive and prognostic markers in the VEGF pathway. What challenges and pitfalls remain for future therapies?......[Read More]
Tacrolimus Concentrations in Kidney Transplant Recipients

Tacrolimus Concentrations in Kidney Transplant Recipients

This study examines the genetic factors which might contribute to the variability of tacrolimus pharmacokinetics in kidney transplant recipients.......[Read More]
Gene Variations and Differences in Myocardial Perfusion

Gene Variations and Differences in Myocardial Perfusion

Do genetic variations in coagulation factors alter patient risk for CAD?......[Read More]
Introduction to the Genomic Medicine Resource Center: Personal Genomics

Introduction to the Genomic Medicine Resource Center: Personal Genomics

Dr. Eric Topol introduces the Genomic Medicine Resource Center with a discussion of personal genomics.......[Read More]
Predicting Sensitivity to Gemcitabine and Cisplatin in NCSLC

Predicting Sensitivity to Gemcitabine and Cisplatin in NCSLC

Does the presence of polymorphisms in certain genes and alterations in their miRNA expression affect in vitro chemosensitivity to cisplatin and gemcitabine?......[Read More]
Quantifying and Qualifying Mutations: We're on Our Way

Quantifying and Qualifying Mutations: We're on Our Way

Dr. George Church considers how new ways to assess genetic mutations will affect our understanding of their clinical relevance.......[Read More]
Predicting Sensitivity to Gemcitabine and Cisplatin in NCSLC

Predicting Sensitivity to Gemcitabine and Cisplatin in NCSLC

Does the presence of polymorphisms in certain genes and alterations in their miRNA expression affect in vitro chemosensitivity to cisplatin and gemcitabine?......[Read More]
miRNAs in Breast Cancer: Ready for Real Time?

miRNAs in Breast Cancer: Ready for Real Time?

miRNAs are now recognized as critical regulators of gene expression. What role do they play in breast cancer pathogenesis, and can they serve as biomarkers and potential therapeutic targets?......[Read More]
A New Therapeutic Target for Hairy Cell Leukemia

A New Therapeutic Target for Hairy Cell Leukemia

Dr. Maurie Markman reviews a recent paper identifying a druggable BRAF mutation in patients with hairy cell leukemia.......[Read More]
Redefining Personalized Medicine in the Primary Care Setting

Redefining Personalized Medicine in the Primary Care Setting

What should a personalized medicine approach be in a primary care practice? Dr. Scott Joy considers both patient and provider perspectives and their impact on the practice of medicine moving forward.......[Read More]
Genomic Data Abound -- Are We Prepared to Use Them?

Genomic Data Abound -- Are We Prepared to Use Them?

Dr. Atul Butte considers the extraordinary strides made in amassing genomic data and the challenges ahead in knowing how to use them effectively.......[Read More]