In most cases, moisturizing after tretinoin is a sensible way to reduce dryness, flaking, and irritation while supporting the skin barrier. It is especially helpful for beginners, people with dry or sensitive skin, and anyone following a nightly retinoid routine. However, if your dermatologist prescribed a bare-skin protocol, you have acne-prone skin that reacts to heavy creams, or your skin is severely irritated, you should pause and ask for guidance. The right choice depends on your skin type, the moisturizer formula, timing, and the instructions you were given.