Should I Kill Lorenzo Cabot?

When It Makes Sense

• Good fit: You want a straightforward legendary weapon reward. Siding with Jack Cabot and killing Lorenzo typically ends the quest with Lorenzo’s Artifact Gun (a gamma gun variant) and preserves the Cabot House dynamic as Jack intended.
• Good fit: You are roleplaying a morally upright or pragmatic Sole Survivor who sees Lorenzo as a dangerous, unstable threat due to his long imprisonment and volatile behavior. Eliminating him aligns with a “protect the Commonwealth” style of play.

When You Should Avoid It

• Warning sign: You want ongoing access to Mysterious Serum from a living source. Freeing Lorenzo gives you an alternative serum supply route and different post-quest interactions, so killing him closes off that branch.
• Warning sign: You are doing a chaotic, anti-authority, or empathetic roleplay where breaking a centuries-long prisoner free fits your character better than helping the controlling Cabot family maintain the status quo.

Pros and Cons

Pros

• You receive a unique legendary weapon, Lorenzo’s Artifact Gun, which can be useful against humanoid enemies and adds a distinctive item to your collection.
• The quest resolves cleanly in favor of Jack Cabot, keeping Cabot House intact and avoiding the risk of Lorenzo causing further chaos in the Commonwealth.

Cons

• You lose access to the alternative reward path and ongoing serum arrangement that freeing Lorenzo provides, which some players find more valuable for survival or immersion.
• If you prefer a mercenary or chaotic playthrough, killing Lorenzo can feel like siding with an arguably manipulative family rather than making an independent choice.

Decision Checklist

• Do I care more about getting a unique legendary weapon now, or about maintaining alternative serum access and a different quest outcome?
• Does my character’s moral alignment lean toward eliminating dangerous threats, or toward skepticism of the Cabot family’s control over Lorenzo?
• Have I saved the game before entering the decision point so I can reload and experience both outcomes?

Alternatives to Consider

If you are unsure, the best alternative is to free Lorenzo Cabot. This path gives you a different reward and quest resolution, and it lets you explore the story from the opposite moral angle. You can also delay the quest until you have a clearer idea of your build and roleplay direction. Because this is a single-player game, you can save before the choice and reload to see both outcomes without any real penalty.

Final Recommendation

Kill Lorenzo Cabot if you want the legendary gun, prefer a clean resolution, and are roleplaying a protective or pragmatic Sole Survivor. Free him if you value alternative rewards, ongoing serum access, or a more rebellious storyline. Since this is a fictional game choice with no real-world stakes, save beforehand and experiment with both paths to see which fits your playthrough best.