Increasing a tirzepatide dose is usually a medical decision, not a self-directed adjustment. It can make sense if you are tolerating your current dose well, have been on it long enough to judge its effect, and are not meeting your glucose or weight-management goals. It is generally unwise to increase the dose if side effects are bothersome, you have certain health conditions, or you have not discussed the change with your prescriber. This guide covers common scenarios, trade-offs, alternatives, and questions to ask your clinician.